Valtrex (valaciclovir, valacyclovir) is a kind of antiviral drug, which is intended to treat disorders caused by herpes viruses. Particularly, it is also widely used for the treatment of cold sores (oral herpes), shingles (herpes zoster) and genital herpes (herpes B.) Also, it is used to get rid of chickenpox in children over 2 years old. It should be noted that this drug alleviates symptoms, but does not treat the virus itself.
Valtrex Mechanism of Action
After absorption from the intestinal tract, generic valacyclovir is converted to acyclovir triphosphate and amino acid valine (in the liver). Acyclovir triphosphate inhibits replication of viral DNA polymerase, as it invades the viral DNA chain and upsets the DNA strand. After that, the virus loses much of its potential and can no longer do any visible damage to the human body. This is how the drug mutes the viruses’ activity.
How to Use Generic Valtrex
Even if you do understand the drug’s mechanism of action, pharmacokinetics, pharmacodynamics, and realize the possibility of side effects, do not use it without consulting your doctor. Once you have the first symptoms characteristic of a herpes virus, call your doctor. Most likely, he/she will prescribe Generic Valtrex to you. If he/she says yes, you can order Valtrex online.
The treatment should start shortly after the first symptoms appear: it will be much less effective if you start using it the next day. Please, try not to skip doses, otherwise, the virus may become immune to the drug.
During the therapy, patients should drink a lot of liquids to prevent damage to kidneys. Treatment can be stopped only when all the symptoms are gone and upon doctor’s advice.
Dosage depends on the type of virus, the severity of the case, as well as patients’ general condition and side effects if any. Valtrex for cold sores is used in the following way: 4 g of the drug each day; two 2 g doses, one in the morning and the other one at night (with a 12-hour interval). Usually, the treatment continues for 7 to 10 days. This is just Valtrex usual dose for adults.
Herpes zoster treatment requires a dose of 1 g every 8 hours for 7 days (for adults). The effect will be observed if the therapy starts at least 48 hours following the appearance of a rash.
For treatment of genital herpes, a dose of 1 g twice daily for 7 days is optimal. The treatment should start at least 48 hours following the appearance of the first signs.
If you have missed your scheduled dose, please, do not try to compensate it by taking two doses at once. Skip it and stick to your schedule. Try not to miss doses later, because it may lessen the effect. If you are undergoing treatment with Valtrex, you still can transmit the infection. The drug does not make the disease less contagious.
Pregnant and breastfeeding women should be cautious because there is not enough data on the drug’s influence on the fetus or milk.
- Hypersensitivity to valacyclovir, acyclovir or any other component of the drug;
- Children under 12 undergoing post-transplantation cytomegalovirus prevention procedures should not use this drug;
- Age under 18 for other indications due to the lack of clinical data for this age group;
- Renal insufficiency.
So far, no clinically significant interactions have been discovered. However, because generic valacyclovir is directly excreted via kidneys, other antiviral, as well as chemotherapy, anti-rejection (used after transplantation) drugs, antibiotics, etc. may affect clearance and harm kidneys.
- Difficulty breathing;
Kidney problems (excretion disorders).